Will TRYNGOLZA (olezarsen), recently approved for familial chylomicronemia syndrome, also lower triglycerides due to other genetic causes of hypertriglyceridemia?

Yes, olezarsen does lower triglycerides due to other causes of hypertriglyceridemia. It is currently in trials in patients with severe hypertriglyceridemia without Familial Chylomicronemia Syndrome (FCS).

Yes. Since olezarsen works by decreasing apoC-III levels and apoC-III is both an inhibitor of lipoprotein lipase and the receptor-mediated clearance of triglyceride-rich remnants by the liver, it would be expected to reduce triglycerides in most settings of hypertriglyceridemia. Indeed, as reported ...