Will you extrapolate EORTC 1333/PEACE-3 (enzalutamide + Rad223) to any other ARPIs for mCRPC?  

Abiraterone is contraindicated in combination with Ra-223, based on the ERA 223 trial, which showed a substantial increase in fracture risk in combination with Ra-223 (29% vs. 11% with abiraterone alone). However, other ARPIs also increased fracture risk compared to ADT alone, although the extent of...