Will you offer patients urea-based creams or topical diclofenac for hand-foot prophylaxis with capecitabine after the D-TORCH trial results?

This study was presented at ASCO, Abstract 12005. Patients with breast or GI cancers treated with single agent capecitabine (1,000 mg/m2 bid) were randomized to treatment with prophylactic diclofenac cream bid x 12 weeks vs placebo. Primary endpoint was incidence of grade 2 or greater HFS. HR for th...

The study has now been peer-reviewed and published (Santhosh et al., PMID 38412399). This was conducted in a single institution, All India Institute of Medical Sciences in New Delhi, India. It was a double-blind randomized controlled trial involving 264 patients randomized to diclofenac gel 1g BID o...

I hope my experience is helpful. Anecdotally, I've used diclofenac gel for years in patients with xeloda HFS. I never used it prophylactically. For patients with severe HFS, I did not find it to be a panacea, and helped a little. For those with moderate HFS, it did seem to help reduce symptoms more ...

Interesting data. Have never tried it, but will think of trying.