With advancing and new therapies emerging for metastatic HER2+ breast cancer, how does one decide between options for third line therapy at time of progression?
Answer from: Medical Oncologist at Community Practice
Barring any contraindications, tucatinib would be my preferred third line after progression on traz/pertuz and ado-traz.
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Answer from: Medical Oncologist at Community Practice
Margetuximab plus eribulin or gemcitabine or vinorelbine, Fam-trastuzumab deruxtecan, neratinib+capeciatbine lapatinib trastuzumab combinations are all Category 2A NCCN recommendations in this setting as well as tucatinib+capeciatbine+trastuzumab.