With recent measles outbreaks occurring in the US, would you consider offering multiple myeloma patients s/p ASCT on maintenance treatment vaccination, or an alternate means of immunity?
Although the MMR vaccine is contraindicated in immunosuppressed patients on anticancer treatment according to CDC/ACIP and IDSA guidelines, data on safety of live vaccines in MM patients on long term maintenance treatment is scarce. A recent small retrospective study (Pandit A et al BMT 2018 ref below) reported on safety outcomes of live-inactivated vaccines (MMR/VZV) in MM patients post-auto on lenalidomide or bortezomib maintenance suggesting one in specific situations might could consider live-attenuated vaccination in MM patients in select circumstances.
In light of the current measles outbreak, what are you doing in practice?
References:
Pandit A. et al Safety of live-attenuated measles-mumps-rubella and herpes zoster vaccination in multiple myeloma patients on maintenance lenalidomide or bortezomib after autologous hematopoietic stem cell transplantation. Bone Marrow Transplant. 2018 Jul;53(7):942-945. doi: 10.1038/s41409-018-0112-x ; <https://www.ncbi.nlm.nih.gov/pubmed/29426830 >
CDC/ACIP and IDSA guidelines
https://www.cdc.gov/mmwr/preview/mmwrhtml/rr6204a1.htm
https://academic.oup.com/cid/article/58/3/e44/336537
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How would you prevent measles viral infection in myeloma patients on long-term maintenance therapy (>24 months) with bortezomib or lenalidomide who do not have detectable measles (rubeola) antibody titres?
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Mednet MemberInvited Expert
Medical Oncology · Winship Cancer Institute of Emory University
Answered on
Measles is on the rise and protection is appealing. The current guidelines for adult immunizations are not clear what patients with monoclonal gammopathy (MGUS), smoldering myeloma (SMM), or multiple myeloma should do. Are they all immunocompromised? Are they all immunocompromised to the same amount...
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