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With the advent of GLP-1 receptor agonist therapy, when (if ever) do you consider adding pioglitazone to patients' diabetes regimen?

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For which of the following patients with type 2 diabetes do you consider adding pioglitazone to a GLP-1 receptor agonist regimen?

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1 Answer
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Endocrinology · Medical University of South Carolina College of Medicine
Answered on

Yes, I do still use pioglitazone, which I believe is underused. I like to consider pioglitazone in patients who have central obesity with leaner legs/arms, i.e., who have a potential mild form of lipodystrophy, and who have hypertriglyceridemia, MASLD/MASH, and insulin resistance. I find that these ...

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