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Would you consider the thymus as an OAR during treatment planning for advanced NSCLC?

Hypothesis-generating results from Prudente et al., PMID 42641684, suggest that mean thymic dose may affect distant metastasis in adult NSCLC. What future data might convince you one way or the other?
3 Answers
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Radiation Oncology · University of Texas at Tyler
Answered on · Updated on

With any avoidance, the dose is pushed further somewhere else, with often unclear effects. You really can rob Peter to pay Paul. I reckon that, as automated, AI-guided OAR contouring occurs, many substructures can be feasibly and reliably drawn and then monitored for associated late effects. It is g...

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Radiation Oncology · UCLA | VA Greater Los Angeles Healthcare System
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Personally, I'd like to see these findings reproduced in at least two other retrospective studies before I would consider them real. If validated, it's time for more rad oncs to use the D2cm and R50 tables when designing IMRT plans to clamp down on intermediate doses that might otherwise spill into ...

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Radiation Oncology · Quillen VA Medical Center
Answered on

DiGeorge Syndrome results from failure of the branchial pouches to develop the parathyroid and Thymus. The Thymus influences the development of the T lineage lymphocytes, surveillance, memory of infection, and all aspects of T-mediated immunity. The thymic “sail” sign in infants and children worried...

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