With the latest hepatitis B guidelines and recent phase 3 trial of Bepirovirsen mentioning the utility of quantifying HBsAg levels, how have you incorporated HBsAg in your practice?

Since the first New England journal publication on Bepi (Yuen et al., PMID 36346079), which demonstrated functional cure in patients with less than 1,000 international units of surface antigen, we’ve been quantifying surface antigen in all of our hepatitis B patients. Almost all the large commercial...

I have started sending qHBsAg on patients who might be future candidates for Bepirovirsen. Labcorp and Quest have the test but often entered incorrectly by their check-in clerks. So far, patients with whom I have discussed the Phase 3 BEPI trial have not been that interested in 24 weeks of SQ inject...