Would having mucinous rectal adenocarcinoma impact your recommendation for short vs long course RT as part of a TNT regimen?   

I would have no problem treating this case with five fractions of 5 Gy followed ~2 weeks later with total neoadjuvant chemotherapy followed by extirpative surgery; with the RT/surgical template similar to that of the investigational arm of the RAPIDO study ( Lancet Oncology 2021; 22: 29-42).  Note...