Topics:
Radiation Oncology • Pediatric Oncology
Would it be appropriate to treat an adult with a pure germinoma at 1.8 Gy/ fraction instead of the pediatric dose of 1.5 Gy/ fx when treating with radiation alone to the whole ventricle (with cone down to primary)?
Answer from: Radiation Oncologist at Academic Institution
We have utilized 1.8Gy per fraction as part of an institutional protocol for CNS germinomas since the 1990s with excellent results (Buckner J JCO 1999). Although the protocol was designed to examine the safety of focal radiotherapy in the setting of CR to induction chemotherapy, this protocol also ...
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