Would it be reasonable to offer a patient with CLL a treatment break from acalabrutinib or any BTK inihibitor after a period of time, assuming good response?

It is certainly reasonable to take breaks and I have done this for certain patients in my practice. For example, in older or frail patients whose disease is already under great control, I think it is reasonable to have a “drug holiday”. With continuous long-term use, it is almost inevitable to run i...