Would the recent use of high dose glucocorticoids impact your selection of first-line therapy for patients with intermediate-poor risk metastatic RCC?
For example, in a patient on steroids for CNS or spinal metastases - would you use IO-IO vs IO-TKI or TKI monotherapy?
Answer from: Medical Oncologist at Academic Institution
Definitely a common clinical scenario, unfortunately. Such patients often have poor risk highly symptomatic disease. In such symptomatic patients, we tend to prefer a VEGF/TKI-based regimen as first line therapy considering the relatively lower rate of primary progressive disease, higher objective r...
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