Would you add an SGLT2 inhibitor to augment diuresis during a hospitalization in a patient with nephrotic syndrome, an eGFR above 30 mL/min/1.73m2, and refractory hypervolemia on an intravenous loop diuretic?

Topics: Nephrology • Glomerulonephritis

Answer from: at Academic Institution

Establish true loop diuretic refractoriness (minimum frequency: BID, the max dose depends on CrCl). Add sequential diuretics. Metolazone or other thiazide-like diuretics, with without amiloride or spironolactone. (Latter diuretics are preferred if the patient is hypokalemic). Add 25% alb...

Comments

at University of Wisconsin School of Medicine and Public Health
Have not used SGLT2i for diuretic use at this time...

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