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Would you add voclosporin to mycophenolate for refractory proteinuria in a patient with low EF?

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Rheumatology · Uniformed Services University of the Health Sciences (USUHS)

There are two major potential concerns in a lupus nephritis patient with systolic dysfunction and a left ventricular ejection fraction (LVEF) of only 30%:

  • QTc prolongation potential worsening leading to acute cardiac death
  • Exacerbation of hypertension leading to worse LVEF and CHF

However, with prop...

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Would you add voclosporin to mycophenolate for refractory proteinuria in a patient with low EF? | Mednet