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How would you approach a situation where you had high clinical suspicion for DKA in a diabetic patient with severe hyperglycemia and elevated anion gap but normal serum pH and bicarbonate?

Could contaminant metabolic alkalosis (e.g. from GI losses) confound the typical acid-base profile of DKA?
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When would you initiate DKA-directed insulin for suspected DKA with severe hyperglycemia, an elevated anion gap, and normal pH and bicarbonate?

14 physicians have voted

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