Would you consider a BRCA carrier patient for kidney transplantation?
I would certainly consider a potential recipient who is a BRCA carrier. Would involve genetic counseling as well as informed consent regarding the risk of malignancy post-transplant. The mortality risk, depending on co-morbidities, of remaining on dialysis is high and should certainly be considered ...
This question reminds me our published case of a hypersensitivity pneumonitis patient who developed two primary cancers-a stage IIIA breast cancer treated with surgery followed by adjuvant chemo/hormonal therapy, and a malignant melanoma treated with surgery only- then required bilateral lung transp...
As long as the patient is informed about the higher malignancy risk associated with the BRCA gene, I do not see a contraindication to transplant. This would also apply to patients with a prior Hx of BRCA malignancy as long as a proper cancer screening is performed and there is an appropriate wait ti...
I agree with my colleagues and would certainly consider BRCA carriers for kidney transplantation. As long as a thorough discussion about risks is performed with the assistance of breast cancer and genetic specialists, the well-known benefits of transplantation outweigh the risks of a potential futur...