Would you consider adding atezolizumab to a different chemotherapy/platinum-doublet backbone from the IMpower 133 trial for a new ES-SCLC patient?

Topics: Thoracic Malignancies • Medical Oncology • Small cell lung cancer

Would you consider adding atezolizumab to a cisplatin/irinotecan regimen, or cisplatin instead of carboplatin?

Answer from: Medical Oncologist at Academic Institution

No I would not, primarily for these reasons: 1) There are no clinical data of which I am aware regarding the addition of atezolizumab to irinotecan and cisplatin for any tumor type. 2) Irinotecan/cisplatin is more toxic than etoposide/platinum regimens, with no improvement in efficacy in 1L extens...

Comments

Medical Oncologist at Florida Hospital Cancer Institute
I agree with @James Stevenson. Without safety data...

Medical Oncologist at Orange Reg Medcl Ctr
I agree.

Medical Oncologist at University of Virginia
I agree as well.

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