Would you consider adding gabapentin off label for use in the treatment of glioblastoma at this time?  

There are a lot of very exciting papers coming out about cancer neuroscience,  and the anti-tumor potential of modulating neurotransmission at brain-glioma synapses and other points of interaction or connection in the nervous system components of the tumor microenvironment. In addition to Dr. J...

In this recent publication from the Brigham and Women's Hospital and UCSF, it was reported that patients who received gabapentin in the post-operative period benefitted with an increase in overall median survival by approximately 4 months: "Median overall survival in patients receiving postoperative...

While this study brings up an interesting point, I’m not convinced that gabapentin should be added to glioblastoma treatment regimens based on these findings. After decades of research and innumerable glioblastoma trials, including those beyond TMZ, we haven’t seen significant progress w...