Would you consider adding gabapentin off label for use in the treatment of glioblastoma at this time?

As an author on the paper, let me emphasize the findings and speculate on the implications. Recently, a number of laboratories have unraveled stunning preclinical and mechanistic findings demonstrating the ability of a subset of malignant glioma cells to usurp neuronal circuitry to promote tumor gro...

In this recent publication from the Brigham and Women's Hospital and UCSF, it was reported that patients who received gabapentin in the post-operative period benefitted with an increase in overall median survival by approximately 4 months: "Median overall survival in patients receiving postoperative...

While this study brings up an interesting point, I’m not convinced that gabapentin should be added to glioblastoma treatment regimens based on these findings. After decades of research and innumerable glioblastoma trials, including those beyond TMZ, we haven’t seen significant progress with systemic...

There are a lot of very exciting papers coming out about cancer neuroscience, and the anti-tumor potential of modulating neurotransmission at brain-glioma synapses and other points of interaction or connection in the nervous system components of the tumor microenvironment. In addition to Dr. Jumper'...