Would you consider age of 70 years as a contraindication (without any other cardiac risks) to use anthracycline in a triple negative breast cancer patient?

Topics: Breast Cancer • Medical Oncology

The ABC trials show a DFS advantage of anthracycline-based regimens. Would age alone procure you from using it in a patient?

Answer from: Medical Oncologist at Academic Institution

As always, it depends. The DFS advantage for anthracycline-based regimens over TCx6 in the ABC trials (J Clin Oncol 35:2647, 2017) was for patients with lymph node involvement, so they were at high risk. In a fit woman who is age 70 or older, the benefits of including the anthracycline likely outw...

Comments

Medical Oncologist at Warren Alpert Medical School of Brown University
I agree with @Gretchen G. Kimmick. It depends upon...

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