Would you consider complement inhibitor therapy or immunosuppressive therapy (e.g. cyclosporine, corticosteroids) for a patient with a PNH clone and early MDS who presents with pancytopenia?

It would depend on the size of the PNH clone and whether or not it was the dominant process as suggested by the depth of the cytopenias and whether there is evidence of hemolysis. I've seen a number of patients with MDS who are concurrently diagnosed with a small PNH clone and I have directed my tre...