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Topics:
Thoracic Malignancies
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Medical Oncology
Would you consider dose modified adagrasib in a patient with NSCLC with KRAS G12C mutation previously treated with sotorasib with excellent response but significant hepatic toxicity necessitating discontinuation?
Related Questions
In patients with driver mutation positive NSCLC who have progressed on targeted therapy and are planned for chemotherapy as the next line of treatment, for which driver alterations do you add in IO and which do you omit IO?
Is there a role for surgical debulking, local RT or subsequent line of chemotherapy for a patient with stable malignant thymoma but active myasthenia gravis?
Would you consider Amivantamab + Lazertinib combo for first line in EGFR mutated metastatic NSCLC, given the recent ESMO updates?
Will you consider definitive concurrent chemoradiation for stage IV lung adenocarcinoma with metastasis limited to an internal mammary lymph node?
Do you think it's appropriate to run separate NGS panels on biopsies from lesions in both the right and left lung in a patient suspected of two lung primaries?
How does the presence of both T790M and L858R EGFR mutations impact the prognosis and management of a patient with previously untreated locally advanced adenocarcinoma of the lung?
How would you manage a patient with stage IV EGFR L858R mutation but with a debilitating drug rash from osimertinib?
Is there a role for nintedanib in the management of patients with radiation-induced pulmonary fibrosis?
Would you consider "consolidation" chemoradiotherapy for a Stage III NSCLC that was initially felt to be too extensive for definitive intent radiotherapy who later experiences a radiographic complete response to carboplatin, paclitaxel, and pembrolizumab?
Has the MARS data for mesothelioma changed whether you would recommend surgery for these patients?