Would you consider GLP1 R agonist therapy in a patient with a history of severe gallstone pancreatitis that is now post cholecystectomy?

In the context of shared decision-making, I would consider prescribing an GLP-1RA on someone with a history of severe gallstone pancreatitis post cholecystectomy. The critical issue is for the patient to understand the uncertainty about the safety of the approach and be willing to take on that risk. In my experience, no one has decided to go for it. It is important to note that there is not a clear cut signal for increased risk of acute pancreatitis in patients treated with GLP-1RA but most studies excluded people with a prior history of pancreatitis.