Would you consider HRT in a young woman (<35 years old) with gBRCA mutated TNBC who underwent bilateral mastectomies and BSO?

I would use HRT for the beneficial effects of bone preservation, lipid improvement, sexual function, and quality of life. My preference is for women to have a concurrent hysterectomy with the BSO so the HRT can be estrogen alone, which has little, if any, risk for promoting breast cancer. In the les...

It depends on the reasons why HRT is recommended, the type of HRT, and the particulars of her case. In general, guidelines still don't routinely endorse HRT in breast cancer patients due to little data on its safety. Mastectomy does reduce the risk of local recurrence, but keep in mind that residual...