Please select the option that best describes you:
Topics:
Radiation Oncology • Melanoma/Skin Cancer • Medical Oncology • Cutaneous Squamous Cell Carcinoma
Would you consider neoadjuvant immunotherapy prior to radiation for a locally advanced skin squamous cell carcinoma?
If so, would you modify your radiation dose/field size to account for immunotherapy response? After how many cycles?
Answer from: Radiation Oncologist at Community Practice
While the definitive trials are yet outstanding and enrollment in NRG HN0014 (NCT06568172) should be encouraged where it is open, the present indications for using cemiplimab should follow its principal indication, unresectable cutaneous squamous cell cancer, a minority of cases at 5%. Practically s...
Sign In or Register to read more
Answer from: Radiation Oncologist at Community Practice
Yes. I have done it for cases that are unresectable or the patient refuses surgery. For example, the PNI of a named nerve. At least 2 cycles, but we often give more to get maximum response. Depends on the response and if there were clinically positive nodes, but I have omitted elective nodal radiati...