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Would you consider offering adjuvant Olaparib to a patient with early stage triple negative breast cancer, cT3N0, ypT1aN0, with BRCA VUS who has residual disease after neoadjuvant KEYNOTE-522 regimen?

Would you be more inclined to use it if a patient had early discontinuation of pembrolizumab due to IRAE?
1 Answer
Mednet Member
Mednet Member
Medical Oncology · Indiana University School of Medicine
Answered on

Patients with TNBC and residual disease have several options. As trials of different approaches ran roughly concurrently, we lack data on how/when to combine, sequence, or choose. The capecitabine and olaparib trials did not include patients on IO therapy that would continue to the adjuvant setting....

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