Would you consider omission of PORT for node+ NSCLC with a positive margin in the setting of a high tumor PD-L1 score and plans for immunotherapy?
Answer from: Radiation Oncologist at Academic Institution
For gross positive margins (R2), no, adjuvant chemoRT followed by consolidation immunotherapy. For R1, SOC would still say PORT and adjuvant systemic therapy. But let's try to tease it out in a more nuanced way from available data. First PD-L1 high is certainly a check in the plus column for a ...
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Answer from: Medical Oncologist at Community Practice
For T1abc–T2aN1, T2bN1, and T3, N0 disease, patients with negative surgical margins (R0) and appropriate biomarkers adjuvant chemotherapy (category 1) followed by atezolizumab, pembrolizumab, or osimertinib is recommended. (Pignon et al., PMID 18506026), (NSCLC Meta-analyses Collaborative Grou...