Would you consider PTH-analog therapy in a woman with osteoporotic vertebral fractures who has asymptomatic non-obstructive renal stones and normal 24-hour urine calcium level?

With the limited information posted, my answer would be yes. I would likely choose abaloparatide as it seems to have less of an issue with hypercalciuria than teriparatide. Another option for an “anabolic" drug would be Romosozumab which would not be a drug about which hypercalciuria is a concern.

I agree with Dr. @Dr. First Last. The mean increase in urinary Ca in the teriparatide phase 3 trial was 30 mg/24 hours. There was rare hypercalcemia in the tptd trial and less in the abaloparatide trial. The tptd trial all patients received full doses of Ca/D. In practice, I estimate the average dai...