Would you consider re-challenging a patient with rituximab after they experienced delayed neutropenia?
In a patient for whom rituximab is the best option for their disease management.
Answer from: at Academic Institution
This is an important question as rituximab is a key treatment option across multiple rheumatic conditions. Probably the best study to inform this question comes from Zonozi et al., PMID 32892495 who retrospectively studied 738 RTX-treated patients at a single institution. They found that late-onset ...
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Answer from: at Academic Institution
3% of patients treated with Rituxan may have delayed neutropenia. I would not re-challenge them with Rituxan and would consider giving the Neupogen to raise the patient's WBC count if it was too low.