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Would you consider replacing ibrutinib with acalabrutinib or zanubrutinib in the TRIANGLE regimen for MCL in a patient with atrial fibrillation or high risk coronary syndromes who is otherwise fit for aggressive induction therapy?

TRIANGLE study
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Would you replace ibrutinib with acalabrutinib or zanubrutinib in the TRIANGLE regimen for MCL in a patient with atrial fibrillation or high risk coronary syndromes otherwise eligible for aggressive induction?

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2 Answers
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Cardiology · The Ohio State University Heart And Vascular Center At Gahanna
Answered on
Generally, if a patient is significantly symptomatic or intolerant due to atrial fibrillation, or other arrhythmia or even heart failure, it is reasonable to consider a next generation BTKI (acalabrutinib or zanubrutinib). As a cardiologist, I will defer to my cancer colleagues on efficacy across ad...

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Medical Oncology · Briseno Kenney Medical Care
Answered on

Yes, but anymore, it depends on whether I can get it paid for!

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