Would you consider SBRT for node negative small cell carcinoma of the prostate?

There are no prospective data to guide the use of RT in the management of small cell carcinoma of the prostate. Retrospective data would suggest possible benefit at least in terms of control of disease in the prostate with the addition of local RT to systemic chemotherapy (see Oke et al., PMID 33824...

Not routinely. In a patient with pure small cell carcinoma of the prostate (meaning no adenocarcinoma features on any of the cores), I have treated with 45 Gy in 30Fx BID to the prostate and gross node, 37.5 Gy in 30Fx BID to the elective nodal volumes. Certainly, if there is any adenocarcinoma comp...