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Would you consider starting with 12 mg of adenosine rather than 6 mg in a hemodynamically stable patient with SVT?

Sert et al., PMID 42057249 - A prospective observational study of 142 adults with ECG-confirmed SVT showed first-dose conversion rates of 83% with 12 mg versus 52% with 6 mg adenosine, with similar adverse effect rates between groups.
2 Answers
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Cardiology · Lankenau Heart Group
Answered on

I know of no data to support higher dose adenosine for SVT termination for any particular clinical scenario. There is a rationale for administering 12 mg if an initial 6 mg doesn't work. In any case, it hardly matters because adenosine is safe at either dose. Any changes in blood pressure or proarrh...

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Cardiology · Baylor College of Medicine/ Texas Children's Hospital
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First, I agree with @Dr. First Last about the safety and rapidity of resolution of effect (also noted in the safety table with no significant difference between 6 and 12 mg). Notably, the doses used in the EP lab after atrial fibrillation ablation to look for dormant pulmonary vein conduction were i...

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