Would you consider telomeropathies as an absolute contraindication to radiation therapy?

No, but it's very relevant to discuss the implications of RT when there is an indication for radiotherapy when consenting a patient.

Many telomeropathies are subclinical/under-diagnosed due to variability in the clinical phenotype (Walsh et al., Clin Cancer Res 2017), but there are clear data both from the preclinical and clinical world to indicate an interaction with RT related injury (Stanley et al., IJROBP 2015) and DNA repair and telomere disorders.

While age is certainly a key predictor of te...