Would you consider ultra-hypofractionated 5 fraction regional nodal radiation in a node + breast cancer who otherwise wouldn't tolerate 16 fractions of RT?

At this time, unless there was a strong reason that hypofractionated breast + RNI in 15-16 fractions couldn't be done, I wouldn't use 5 fx breast + RNI off-trial. If compelling reasons, one could consider extrapolating safety of breast RT from FAST/FAST-Forward and axilla from melanoma data.

At this time, outside of a clinical trial, I would not consider 5-fx CW/breast + RNI. If significantly extenuating circumstances existed, it could be considered, but the patient and their family would need extensive counseling, as it's not currently standard of care and has potential risks associate...