Would you consider using DOACs in a young patient with SLE and Libman-Sacks endocarditis, who is negative for APS?

Topics: Pediatric Oncology • Rheumatology • AYA • Thrombosis • Hematology • Pediatric Hematology • Systemic lupus erythematosus • Benign Hematology • Cardiology • Cardio-Rheumatology • Anticoagulation

Answer from: at Academic Institution

In this scenario, our patient with lupus is young and does not have features of APS. Nevertheless, any patient with Libman Sacks endocarditis carries a heightened risk for embolization. Regarding anticoagulation, the literature on this subject is anecdotal and conflicting with some authors recommend...

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at Indiana Hemophilia and Thrombosis Center
Thank you Dr. @Simon M. Helfgott, this is very hel...

Answer from: at Community Practice

The benefit of anticoagulation has not been demonstrated convincingly for infective endocarditis patients. In fact, anticoagulation could be harmful for such patients. When the thrombus embolizes, there is a high chance of hemorrhagic conversion especially, in anticoagulated patients. I am not entir...

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