In a patient with metastatic pancreatic cancer with diffuse liver metastases, would you consider whole-liver radiation to lower bilirubin so that they are daraxonrasib eligible?

I think it is an interesting idea. However, I would not expect the TB to decline after RT. Stable, maybe, but not a decline. If TB is rising, that is from parenchymal destruction, and radiation will not reverse it. If obstructive, only stenting would make sense.