Would you continue pembrolizumab in an asymptomatic metastatic NSCLC patient with high PD-L1, who develops granulomatous mediastinal lymphadenopathy biopsy proven as sarcoid?

Topics: Thoracic Malignancies • Medical Oncology • NCI-CCC Tumor Board Question • Ohio State University • NCI-CCC Thoracic Tumor Board Question

Answer from: Medical Oncologist at Academic Institution

Sarcoid-like granulomatous reactions have been described with checkpoint inhibitors. It is important to diagnose them when they occur, in order to not confuse these findings with disease progression, especially in a patient with lung cancer. I have had two patients at least show growing mediastinal ...

Comments

Medical Oncologist at McLeod Regional Medical Center at McLeod Seacoast
The key issues are whether or not the granulomatou...

Related Questions