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Would you continue pembrolizumab in an asymptomatic metastatic NSCLC patient with high PD-L1, who develops granulomatous mediastinal lymphadenopathy biopsy proven as sarcoid?

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Mednet Member
Mednet Member
Medical Oncology · Indiana University

Sarcoid-like granulomatous reactions have been described with checkpoint inhibitors. It is important to diagnose them when they occur, in order to not confuse these findings with disease progression, especially in a patient with lung cancer. I have had two patients at least show growing mediastinal ...

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Would you continue pembrolizumab in an asymptomatic metastatic NSCLC patient with high PD-L1, who develops granulomatous mediastinal lymphadenopathy biopsy proven as sarcoid? | Mednet