Would you continue serial PSMA PET scans after 2 negative scans for patients with a persistently rising PSA post-RT?

PSA > 2, and PSA doubling time < 1yr. Patient is resistant to ADT and did not tolerate the primary treatment. Would alternative PET imaging be recommended?

Answer from: Radiation Oncologist at Academic Institution

Some context would probably be helpful for this. E.g., PSA >2 is different for a patient post-prostatectomy vs. post-radiotherapy. But, in general, if clinical suspicion of cancer recurrence/progression is high, and PSMA PET is negative, one can consider the following options: There may not be...

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Medical Oncologist at Kettering Cancer Care
Agree with the above. If PSA continues to increase...

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Would you continue serial PSMA PET scans after 2 negative scans for patients with a persistently rising PSA post-RT?

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