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Would you continue spironolactone in a patient who has recently progressed to ESKD on HD with oliguria and was diagnosed with primary hyperaldosteronism years ago?

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Would you continue spironolactone in a patient who has recently progressed to ESKD on HD with oliguria and was diagnosed with primary hyperaldosteronism years ago?

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1 Answer
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Nephrology · UCLA
Answered on

Although spironolactone does antagonize the effect of aldosterone in the colon, it is unlikely that spironolactone will be effective in treating primary hyperaldosteronism in a patient with ESKD with minimal urine output. Therefore, I would discontinue the spironolactone in such patients.

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