Would you ever consider SRS as a salvage option as an alternative to whole brain radiation for secondary CNS lymphoma?

The optimal management of secondary CNS lymphoma is not clear. Clinical considerations include the age and performance status of the patient, distribution of disease (CNS only versus systemic and CNS), prior treatment, etc. In most cases, high-dose methotrexate (HD MTX) based regimens are pursued. I...

This is a great question, as the dominant paradigm for radiation treatment for CNS lymphoma has historically been WBRT, often with expanded fields (inclusion of posterior globe, etc) compared to WBRT for brain metastases or other consolidation regimens.

Most of the data is confined to retrospective s...