Would you give chemotherapy to a fit patient with myxoid liposarcoma of the knee that is resectable with adverse functional outcomes who will be undergoing neoadjuvant radiation and resection?

I give ifosfamide to people with myxoid/round cell liposarcoma.

In general, I do not give adjuvant chemotherapy to adult-type soft tissue sarcomas because of the phase 3 EORTC studies showing that it did not improve survival.

Le Cesne et al., PMID 25294887

But I do give ifosfamide to people with myxoi...