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Would you give consolidation durvalumab to a patient who underwent chemoradiation for his stage III NSCLC and is being started on antifibrotic therapy by pulmonology for his ILD?

How does the patient's pulmonary status and ECOG-PS play a role in your decision? This patient has an ECOG-PS of 0 and is on room air.
1 Answer
Mednet Member
Mednet MemberInvited Expert
Medical Oncology · University of Minnesota Medical School
Answered on

This is a difficult scenario. On the one hand, we know from the PACIFIC trial that there is a clear benefit to the addition of durvalumab in this setting. On the other hand, there is a higher risk of pneumonitis due to both the prior use of radiotherapy and the history of underlying ILD. I think ECO...

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