In the general population of colorectal cancer patients with upfront resectable liver metastatic disease with low clinical risk, resection followed by a risk–benefit discussion regarding adjuvant chemotherapy or surveillance is appropriate. Fluorouracil-based chemotherapy compared to observati...

Agree with the above excellent summary. I would discuss the last paragraph with the patient and would suggest the following if no trial is available: If cDNA is negative, just observation and initiation of immunotherapy when demonstrable recurrence. In the likely setting of positive ctDNA, offer...