Would you offer adjuvant chemotherapy/immunotherapy for resected pure squamous cell carcinoma (T2-T4 or N+/-) of the renal pelvis?
If you do recommend adjuvant therapy, what regimen would you use?
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What adjuvant therapy will you offer to squamous cell carcinoma of upper urinary tract after nephro-ureterectomy?
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2 Answers
Mednet MemberInvited Expert
Medical Oncology · VCU Massey Comprehensive Cancer Center
Answered on · Updated on
Primary or pure squamous cell carcinoma of renal pelvis is very rare and the role of adjuvant therapy after surgery is unknown. Squamous cell carcinomas in head-neck, anal and other sites, tend to recur locally. Based on that behavior, I would offer radiation with a sensitizer, preferably weekly cis...
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Mednet MemberInvited Expert
Medical Oncology · AdventHealth Cancer Institute
Answered on
There are no definitive data in the setting of adjuvant therapy for high-risk (>=pT3 or N+) predominant or pure squamous cell carcinoma of the urinary tract who have undergone upfront definitive surgery. Given the locoregional recurrence risk is quite important in squamous cell carcinoma, adjuvant c...
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