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Would you offer adjuvant immunotherapy (pembrolizumab) for chromophobe RCC with R1 resection?

Adjuvant IO therapy, radiation therapy, both, or neither?
1 Answer
Mednet Member
Mednet MemberInvited Expert
Medical Oncology · The University of Texas Health Science Center at San Antonio
Answered on

I have not experienced this situation yet in my own clinical practice but I would not offer adjuvant IO nor adjuvant radiation therapy for this patient.

  1. IO therapy has limited efficacy in this histology. This was shown best in the KEYNOTE-427 (monotherapy pembrolizumab in metastatic nccRCC, McDermo...

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