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Would you offer adjuvant pembrolizumab to a stage II-III adenocarcinoma of the lung who had a complete pathologic response to 4 cycles of cisplatin/pemetrexed/pembro (KN-671)?

And would your answer be different if you had used pre-op nivolumab (CM-816)?
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Would you still recommend adjuvant pembrolizumab to a stage II-III NSCLC who had a pathologic CR to neoadjuvant cisplatin/pemetrexed/pembro (KN-671)?

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2 Answers
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Medical Oncology · Indiana University School of Medicine
Answered on

The question posed is a central question of investigation and debate today.

In my view, the patients most likely to derive benefit from adjuvant immunotherapy after receiving neo-adjuvant chemo-immunotherapy are those with the best responses to neo-adjuvant therapy. The patients I would least likely ...

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Medical Oncology · Mary Lanning Healthcare Morrison Cancer Center/University of Nebraska Medical Center Adjunct Faculty
Answered on · Updated on

For perioperative systemic therapy of NSCLC, current NCCN guidelines recommend neoadjuvant chemoimmunotherapy if patients are eligible for immune checkpoint inhibitors; the two listed options include either neoadjuvant nivolumab and platinum doublet chemotherapy every 3 weeks for 3 cycles followed b...

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