Would you offer adjuvant radiation for a grade 1 osteosarcoma of the mandilbe with close margins following surgical resection?

There is a good rationale for offering post-op RT in this setting. A relevant retrospective series from MDACC reported on ~120 patients who underwent surgery with or without RT (Guadagnolo et al., PMID 19382187). In this report, approximately 40% developed local recurrence, speaking to the high rate...

Yes.