Would you offer adjuvant radiotherapy for a malignant fibromyxoid tumor of soft tissue with margin < 1 cm on re-excision?

Malignant ossifying fibromyxoid tumors are very rare and from a pathologic perspective, often get lumped under the tumors of intermediate malignant potential and of uncertain differentiation category.

The expectation that the histologically malignant fibromyxoid tumors behave malignant, and thus I would recommend adjuvant radiation therapy in this setting.

The dose and fractionation would depend on the initial surgery and the presence of focal vs diffuse positive margins. In this scenario, I would delineate my dose and tailor this based on the location. My preference would be to treat to 66 Gy in 33 fractions, particularly if the positive margins on initial resection were diffuse. If the location is near critical structures, then you could ...

No if grade 1-2. Yes if grade 3. So likely no.