Would you offer BM biopsy as the next step for progressive thrombocytosis when peripheral blood is negative for JAK2, CALR, and MPL mutations for MPN diagnosis?
Answer from: Medical Oncologist at Community Practice
Yes, definitely. Always need bone marrow morphology to diagnose MPNs. Triple-negative ET or PMF comprises 5-10% of all ET and PMF and lacks the 3 canonical driver mutations, i.e., in the JAK2, CALR, and MPL genes.
Comments
Medical Oncologist at Wentworth Douglass Hospital What if it is stable non-progressive thrombocytosi...
Medical Oncologist at The Center for Hematology and Oncology at Holy Cross Hospital Agree with marrow evaluations
What if it is stable non-progressive thrombocytosi...
Agree with marrow evaluations