Would you offer BM biopsy as the next step for progressive thrombocytosis when peripheral blood is negative for JAK2, CALR, and MPL mutations for MPN diagnosis?
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Would you offer BM biopsy as the next step for progressive thrombocytosis when peripheral blood is negative for JAK2, CALR, and MPL mutations for MPN diagnosis?
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1 Answer
Mednet MemberInvited Expert
Medical Oncology · The University of Texas, M.D. Anderson Cancer Center
Answered on
Yes, definitely. Always need bone marrow morphology to diagnose MPNs. Triple-negative ET or PMF comprises 5-10% of all ET and PMF and lacks the 3 canonical driver mutations, i.e., in the JAK2, CALR, and MPL genes.
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