Would you offer definitive CRT for stage III(N3) NSCLC treated with neoadjuvant immunotherapy who had a complete radiographic response?

I am not aware of any strong data supporting the omission of definitive local therapy based on response to neoadjuvant systemic treatment. Would strongly recommend definitive chemoRT. If the patient is not a candidate for chemotherapy, then hypo-fractionated RT (45-60 Gy in 15 fractions).

In genera...

Data free space and one that is fit for a well designed study to consider dose de-escalation of radiotherapy. First, I think it's quite unlikely you are going to have a true "complete radiographic response" to neoadjuvant IO. Whether there remains any viable tumor present is one thing but you are al...